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Maternal Environmental Factors Associated with Congenital Hydrocephalus

Maternal Environmental Factors Associated with Congenital Hydrocephalus


  • Rahat Bano Siddiqui
  • Uzma Erum Alama General Hospital, Kingdom of Saudi Arabia
  • Rabia Rauf Niazi Medical and Dental College, Sargodha
  • Shumaila Shakoor Lahore Medical and Dental College, Lahore
  • Sabahat Zulfiqar Nawaz Sharif Medical College, Gujrat
  • Mehwish Razzaq Karachi Institute of Medical Sciences/CMH



Congenital, Congenital hydrocephalus, Maternal factors


Background: Congenital hydrocephalus is characterized by dysregulated cerebrospinal fluid circulation and is associated with serious morbidity. The objective of this study was to identify the various maternal factors related to the occurrence of congenital hydrocephalus.

Patients and methods:  This was a retrospective study conducted at the University of Health Sciences, Lahore (UHS) and Children’s Hospital and Institute of Child Health. A total of 96 patients of congenital hydrocephalus along with their mothers were enrolled in this study. Data was collected by using proforma for history taking from mothers regarding antenatal period and family history details. Collected data was entered, processed, and analyzed in SPSS version 21.0.

Results: The mean maternal age of the participants was 27.88 ± 5.36 years. The results of maternal parity showed a mean of 2.85 ± 1.86 children. A history of self-medications including analgesics, over-the-counter antibiotics and herbal medicines used in the first trimester was found in 53 (55.2%) mothers. Eighty (83.3%) mothers did not take folic acid supplementation during pregnancy compared to only 16 (16.7 %) mothers who regularly took folic acid. No mother was reported to be a smoker or alcoholic. A family history of congenital HCP was reported by 10 (10.4%) mothers. Consanguinity history showed that 40 (40.7%) patients had consanguineous marriages while 56 (58.3%) had non-consanguineous marriage histories.

Conclusion: The common maternal factor associated with the occurrence of congenital hydrocephalus was the lack of regular folic acid supplementation during antenatal care.




How to Cite

Siddiqui RB, Erum U, Rauf R, Shakoor S, Zulfiqar S, Razzaq M. Maternal Environmental Factors Associated with Congenital Hydrocephalus. J Fatima Jinnah Med Univ [Internet]. 2024 Apr. 20 [cited 2024 Jul. 15];18(01):25-8. Available from: