Estimation of Glomerular Filtration Rate Using Inverse of Serum Creatinine and Pulse × Mass Index - An Underestimated Tool
Abstract
Objective: In western world MDRD and Cockcroft & Gault equations (CG) are widely used for GFR estimation. Pulseass Index (PMI) is known cardiovascular risk factor. In year 2005 Enrique J,Sanchez-Delgado suggested the calculation of GFR by using 1/S.Cr and PMI. He proposed that 1/S.Cr/PMI will not only calculate GFR but also predict cardiovascular mortality. The present study was undertaken to compare accuracy of GFR calculated by 1/S.Cr/PMI (GFR-PMI) with MDRD and CG equations.
Design: Prospective study
Place and duration of study: Nephrology Department, Sheikh Zayed Hospital, Lahore. Three months.
Patients and Methods: The study included 112 subjects between 15 to 70 years of age. Body weight and height and resting heart rate were measured. Serum sample was taken for analysis of creatinine, albumin, and urea nitrogen. Patients were divided into different groups based upon age, sex, albumin and serum creatinine level and GFR-PMI was compared with CG and MDRD equations using 2 sample t-tests.
Results: CG equation and GFR-PMI showed same results in all groups except when age was >60 years. When GFR-PMI was compared with MDRD-4 variable equation, similar results were found only at S.Cr less than 1 mg/dl and age less than 40 years.
Conclusion: The results determined both by GFR-PMI and CG equation were found to be similar. Although GFR-PMI equation has the edge that it not only estimates GFR but also predicts the cardiovascular mortality risk. As the MDRD equation has no proven validity in Pakistani population, its results are different from GFR-PMI and CG equations
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