Effect of Rhodiola Extracts on Learning, Memory Deficits and Micro Structure of Brain Cells Induced by Sleep Deprivation
Keywords:
sleep deprivation; Rhodiola; brain cells; micro structureAbstract
Objective:To Study the effect of Acanthopanax senticosus extract on the brain cell ultrastructure of rats model of sleep deprivation and its learning and memory deficits.
Material and Methods: Brain cells ultrastructure were observed by transmission electron microscopy, rat model of sleep deprivation were made by using a modified multiple platform water environmental law, learning and memory ability were assessed by a maze test in rats.
Results: In rat model of sleep deprivation group (SD group) there was obvious brain cell injury, learning and memory deficits and increased reaction time as compared to cage control group ( group CC) and tank control group ( group TC) ( p<0.05, p<0.01 ). In treatment group ( ST group ) with Acanthopanax senticosus, the brain cell injury was lighter, learning and memory deficits were reduced and reaction time was shortened ( p<0.05 ) than that in SD group.
Conclusion: The results showed that extract of Acanthopanax senticosus can improve brain cells injury induced by sleep deprivation and can improve learning and memory deficits in sleep deprived rats.
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