Diagnostic accuracy of toluidine blue in early detection of oral squamous cell carcinoma

  • Muhammad Salman Chishty
  • Malik Ali Hassan Sajid FMH College of medicine & Dentistry Lahore
  • Shoaib - Younus
  • Usman Ul Haq
Keywords: Oral Squamous cell carcinoma, Pre-malignant lesion, Diagnostic accuracy, Toluidine blue

Abstract

Background: Indian sub-continent (India, Pakistan, and Bangladesh) is one of the high-risk populations for oral cancer cases. Intraoral screening is critical to diagnosis and treating oral cancer at an early stage for a better prognosis. Among the diagnostic adjuncts, toluidine blue staining is considered a simplistic, cost-effective, and highly sensitive method. The objective of the current study was to find out the diagnostic accuracy of toluidine blue in the early detection of oral squamous cell carcinoma.

Patients and methods: This prospective observational study was undertaken at the Department of Oral and Maxillofacial Surgery, Institute of Dentistry, CMH Lahore Medical College from15-09-2019 to 15-03-2020 after getting approval from IRB.  Based on inclusion criteria, a sample size of 100 was calculated and enrolled in the study. Non-probability convenient sampling technique was utilized. Oral staining of 100 patients was done with 1% toluidine blue on an OPD basis, and incisional biopsies were then performed. Staining pattern and histopathology reports of patients were evaluated to assess the diagnostic accuracy

Results: The study results revealed the sensitivity of Toluidine Blue as 89.87%, and specificity of toluidine blue was found as 76.19%. Positive and negative predictive values of Toluidine Blue remained 93.42% and 66.67%, respectively.

Conclusion: Toluidine blue has good diagnostic accuracy for early detection of oral squamous cell carcinoma (SCC).

Author Biographies

Muhammad Salman Chishty

 

Assistant Professor, Department of Oral and Maxillofacial Surgery,

Institute of Dentistry, CMH Lahore Medical College.

 

 

 

Shoaib - Younus

 

 

Associate Professor, Department of Oral and Maxillofacial Surgery,

Institute of Dentistry, CMH Lahore Medical College.

 

 

Usman Ul Haq

 

 

Assistant Professor, Head of Departmentof Oral and Maxillofacial Surgery,

HITEC-IMS Dental College, Taxila Cantt.

 

 

 

 

 

Published
2021-12-07
How to Cite
1.
Chishty M, Sajid MA, Younus S, Haq U. Diagnostic accuracy of toluidine blue in early detection of oral squamous cell carcinoma. J Fatima Jinnah Med Univ [Internet]. 7Dec.2021 [cited 25May2022];15(2):91-4. Available from: https://jfjmu.com/index.php/ojs/article/view/850