Study of Insulin Resistance in Male and Female Diabetics

  • M ZAMIR AHMAD, TALMEEZ ZEB SHAH, SHAMIM AKRAM, MUHAMMAD MUSTANSAR
Keywords: hyperglycemia, hyperinsulinemia. insulin resistance ,diabetic type 2

Abstract

ABSTRACT

Objectives: To determine the insulin resistance in diabetic type 2 males and females in the fasting state in the population of Lahore, Pakistan.

Methods: The study group comprised of 122 individuals (49 males and 73 females), who were > 30 years old. Parameters, serum glucose and serum insulin levels were estimated in fasting state and based on those, the insulin resistance indices (IRI) was calculated by HOMA-IR 1 in the total sample population, in males and in females separately.

Results: The study group had increased average levels of serum glucose (10.008 + 0.326 mmol/L) and insulin resistance indices (5.370 + 0.396) when compared with the normal adult population. There was no difference based on gender. IRI was significantly different based on groups of W/ht in males. On the other hand, the correlations of all the clinical parameters with their respective serum glucose, serum insulin and IRI were strongly positive (r > 0.8) and highly significant (p value < 0.001) irrespective of gender status and parameter type.

Conclusion: The results for anova could mean that the fat distribution only in males is responsible for metabolic derangements; though the results for correlation show no discrimination based on gender.

 

Published
2018-11-22
How to Cite
1.
SHAMIM AKRAM, MUHAMMAD MUSTANSAR MZATZS. Study of Insulin Resistance in Male and Female Diabetics. J Fatima Jinnah Med Univ [Internet]. 22Nov.2018 [cited 30Sep.2022];10(3). Available from: https://jfjmu.com/index.php/ojs/article/view/91