Evaluation of Complications in Children after Liver Transplantation: A Single Centre Study

Keywords: Liver transplantation, Complications, Infections, Drugs, Electrolytes


Objective: To evaluate complications in children after liver transplantation so an early referral and appropriate management could be instituted to improve the late outcome.

Study Design: Retrospective observational study.

Place and Duration of Study: The study was carried out at the Department of Pediatric Gastroenterology, Hepatology & Nutrition, KFSH&RC, Jeddah, Kingdom of Saudi Arabia. The data between 1/10/2006 and 1/10/216 was included and analysed.

Materials and Methods:

Sample Size: 15 patients fulfilled the criteria of selection and were recruited in the study.

Sampling Technique: The data was collected from the hospital’s electronic records: power chart system.

Data Collection Procedure: A spread sheet was designed to collect data regarding demographics, primary diagnosis, long-term morbidity such as drug related complications, viral and bacterial infections, recurrence of cholestasis and primary disease, lympho-proliferative disease and graft versus host disease.

Data presentation: The data was presented in percentages and frequencies in the form of charts and a table.

Results: Among 15 children 12 were males, male to female ratio was 4:1. The median age at liver transplant was 2.5 years. Eight patients (53%) had either one or more episodes of bacterial infections, in the form of UTI, Sepsis, and throat infection. Five children (34%) developed EBV infection and 3 (20%) had CMV infection. Hypomagnesaemia was found in 14 (93%) children, while hyperphosphataemia and hypophosphatemia were noted in 9 (60%) and 5(33%) children respectively. Three (20%) children developed renal failure. Two (13%) children had recurrence of cholestasis, 1 (7%) child developed biliary stricture and another (17%) had chronic rejection. Only one child expired and the overall survival rate was 93%.

Conclusion: Infections and drugs related electrolyte abnormalities were the most common complications noted in children, 6 months after liver transplantation. With early detection and appropriate management, majority of complications could be detected and managed, which would have an impact on the long term survival.

How to Cite
IQTADAR SEERAT MAA. Evaluation of Complications in Children after Liver Transplantation: A Single Centre Study. J Fatima Jinnah Med Univ [Internet]. 22Nov.2018 [cited 31Jan.2023];10(4). Available from: https://jfjmu.com/index.php/ojs/article/view/99